Recent evidence demonstrates that peripheral immune cells contribute to the nociceptive
hypersensitivity associated with neuropathic pain by infiltrating the central nervous system
(CNS). We have recently developed a rat model of graded chronic constriction injury (CCI)
by varying the exposure of the sciatic nerve and control non-nerve tissue to surgical
placement of chromic gut. We demonstrate that splenocytes can contribute significantly to
CCI-induced allodynia, as adoptive transfer of these cells from high pain donors to low pain …